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・ Endosulfan
・ Endosymbiont
・ Endotec
・ Endothall
・ Endothamna marmarocyma
・ Endothelial activation
・ Endothelial colony forming cell
・ Endothelial dysfunction
・ Endothelial lipase
・ Endothelial NOS
・ Endothelial progenitor cell
・ Endothelial protein C receptor
・ Endothelial stem cell
・ Endotheliitis
・ Endothelin
Endothelin 1
・ Endothelin 2
・ Endothelin 3
・ Endothelin converting enzyme 1
・ Endothelin receptor
・ Endothelin receptor antagonist
・ Endothelin receptor type A
・ Endothelin receptor type B
・ Endothelin-converting enzyme 1
・ Endothelium
・ Endothelium-derived hyperpolarizing factor
・ Endothelium-derived relaxing factor
・ Endothenia
・ Endothenia euryteles
・ Endothenia gentianaeana


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Endothelin 1 : ウィキペディア英語版
Endothelin 1

Endothelin 1, also known as preproendothelin-1 (PPET1), is a protein that in humans is encoded by the ''EDN1'' gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 is one of three isoforms of human endothelin (ET-1).
Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.
Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Inhibition of these receptors prevents pulmonary vasculature constriction and thus decreases pulmonary vascular resistance.
==References==


抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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